Santee River

Santee River, River, southeast-central South Carolina, U.S. The Santee flows southeast into the Atlantic Ocean after a course of 143 mi (230 km). It has been dammed to form the reservoir Lake Marion, which is connected by a navigable waterway, Lake Moultrie, and the Cooper River to Charleston. The entire river system is the most important waterway and source of hydroelectric power in South Carolina.