Marchiafava-Bignami disease

…uncommon chronic brain disorder called Marchiafava-Bignami disease, which involves the degeneration of the corpus callosum, the tissue that connects the two hemispheres of the brain. Other brain damage occasionally reported in alcoholics includes cortical laminar sclerosis, cerebellar degeneration, and central pontine myelinolysis

…also occur in patients with Marchiafava-Bignami disease, a rare alcoholism-related condition, but the more global brain damage associated with this disease leads to stupor, seizures, and coma, rather than the features typical of split-brain syndrome.)

…affecting the corpus callosum include Marchiafava-Bignami disease, which is characterized by progressive demyelination of the neurons of the corpus callosum. In addition, agenesis (imperfect development) of the corpus callosum can cause intellectual disability and seizures. A reduced amount of tissue in the corpus callosum also has been associated with