vagus nerve, longest and most complex of the cranial nerves. The vagus nerve runs from the brain through the face and thorax to the abdomen. It is a mixed nerve that contains parasympathetic fibres. The vagus nerve has two sensory ganglia (masses of nerve tissue that transmit sensory impulses): the superior and the inferior ganglia. The branches of the superior ganglion innervate the skin in the concha of the ear. The inferior ganglion gives off two branches: the pharyngeal nerve and the superior laryngeal nerve. The recurrent laryngeal nerve branches from the vagus in the lower neck and upper thorax to innervate the muscles of the larynx (voice box). The vagus also gives off cardiac, esophageal, and pulmonary branches. In the abdomen the vagus innervates the greater part of the digestive tract and other abdominal viscera.

The vagus nerve has the most extensive distribution of the cranial nerves. Its pharyngeal and laryngeal branches transmit motor impulses to the pharynx and larynx; its cardiac branches act to slow the rate of heartbeat; its bronchial branch acts to constrict the bronchi; and its esophageal branches control involuntary muscles in the esophagus, stomach, gallbladder, pancreas, and small intestine, stimulating peristalsis and gastrointestinal secretions.

Vagus nerve stimulation, in which the nerve is stimulated with pulses of electricity, is sometimes used for patients with epilepsy or depression that is otherwise untreatable; the technique has also been explored for conditions such as Alzheimer disease and migraine.

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The Human Body