sulfonylurea

Sulfonylureas, RSO₂NHC(O)NRR′, which are widely used herbicides, inhibit acetolactic synthase, a key plant enzyme. Anticlotting medical plastics have been prepared containing sulfonated polymers that bind heparin, a natural polysulfate. Sulfonamides, RSO₂NH₂, played an important role in the development of certain medicines. Sulfanilamide,

Sulfonylureas, such as glipizide and glimepiride, are considered hypoglycemic agents because they stimulate the release of insulin from beta cells in the pancreas, thus reducing blood glucose levels. The most common side effect associated with sulfonylureas is hypoglycemia (abnormally low blood glucose levels), which occurs…

The sulfonylureas, for example, stimulate the insulin-secreting beta cells of the pancreas to produce more insulin. With long-term use, this effect appears to diminish, but plasma glucose levels remain low. The most serious adverse effect of these drugs, which occurs only rarely, is profound hypoglycemia; in…