vaccine-associated paralytic polio

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vaccine-associated paralytic polio

Also known as: VAPP, vaccine-associated paralytic poliomyelitis

Learn about this topic in these articles:

history of polio vaccines

In polio vaccine: Historical developments
OPV also can cause vaccine-associated paralytic poliomyelitis (VAPP). As a result, in the 21st century, many high-income countries transitioned back to IPV, which is not associated with a risk of VDPV. Affordable IPV strategies also were under development for low-income countries.
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occurrence

In polio: Treatment and vaccination
…of what is known as vaccine-associated paralytic polio (VAPP) in both vaccine recipients and their contacts. Such cases occur once in every two million or more doses of OPV. VAPP appears to be caused by a reversion mutation of attenuated virus, thereby converting the virus back to an infectious form…
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